(CAS NO. 57465-28-8)
(CAS NO. 31508-00-6)
Female rats administered the mixtures of PCB 126 and PCB 118 developed a variety of diseases in several organs, including cancers of the liver, lung, and mouth.
A variety of other toxic lesions observed in exposed animals included
fibrosis, and necrosis of the liver
hyperplasia of the oral mucosa
metaplasia of the lung
atrophy of the thymus
hypertrophy of the thyroid gland
atrophy of the adrenal cortex
vacuolization and atrophy of the pancreas
hyperplasia of the nose
hyperplasia of the forestomach
hemorrhage of lymph nodes and brain
atrophy of the spleen.
We conclude that the mixtures of PCB 126 and PCB 118 caused cancer and other toxic effects at several sites in female rats.
niehs.nih.gov: Paper published