Toxicological Profile for Chlorinated Dibenzo-p-dioxins (CDDs)

Toxicological Profile for Chlorinated Dibenzo-p-dioxins (CDDs)

December 1998
(with updated policy guideline in Appendix B for residential soil, September 2008)

Toxicological Profile PDF PDF Version, 10.2 MB

Toxicological Profile Information

The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. Each peer-reviewed profile identifies and reviews the key literature that describes a hazardous substance’s toxicologic properties. Other pertinent literature is also presented, but is described in less detail than the key studies. The complete list of topics covered (chapter titles) is shown at the left and in more detail further down this page.

The focus of the profile is on health and toxicologic information. Therefore, each profile begins with a Public Health Statementthat summarizes in nontechnical language, a substance’s relevant properties.

A useful two page information sheet, the ToxFAQs™, is also available.

Toxicological Profile Access

In order to access the ATSDR toxicological profiles’ PDF files below, you must have Adobe Acrobat Reader .

You may download that program for free from this link to Adobe Exiting the ATSDR Web Site. and then use it to access (open) the files below that are labeled as PDF files.

Toxicological Profile PDF Complete Profile, 10.2 MB

The table of contents and list of individual PDF files are given below.

Preface PDF Preface, 201 KB

  • Disclaimer
  • Update statement
  • Foreword
  • Quick reference
  • Contributors
  • Peer review
  • Contents
  • List of figures
  • List of tables

Public Health Statement PDF 1. Public Health Statement, 128 KB

1.1 What is this substance?
1.2 What happens to it when it enters the environment?
1.3 How might I be exposed to it?
1.4 How can it enter and leave my body?
1.5 How can it affect my health?
1.6 How can it affect children?
1.7 How can families reduce the risk of exposure?
1.8 Is there a medical test to determine whether I have been exposed to it?
1.9 What recommendations has the federal government made to protect human health?
1.10 Where can I get more information?

Health Effects PDF 2. Health Effects, 5.5 MB

2.1 Introduction
2.2 Discussion of health effects by route of exposure
2.3 Toxicokinetics
2.4 Mechanisms of action
2.5 Relevance to public health
2.6 Biomarkers of exposure and effect
2.7 Interactions with other substances
2.8 Populations that are unusually susceptible
2.9 Methods for reducing toxic effects
2.10 Adequacy of the database
Chemical and Physical Information PDF 3. Chemical and Physical Information, 702 KB

3.1 Chemical Identity
3.2 Physical and Chemical Properties
Production, Import, Use, and Disposal PDF 4. Production, Import, Use, and Disposal, 141 KB

4.1 Production
4.2 Import / Export
4.3 Use
4.4 Disposal
Potential for Human Exposure PDF 5. Potential for Human Exposure, 1.9 MB

5.1 Overview
5.2 Releases to the environment
5.3 Environmental fate
5.4 Levels monitored or estimated in the environment
5.5 General population and occupational exposure
5.6 Populations with potentially high exposure
5.7 Adequacy of the database
Analytical Methods PDF 6. Analytical Methods, 1.1 MB

6.1 Biological materials
6.2 Environmental samples
6.3 Adequacy of the database
Regulations and Advisories PDF 7. Regulations and Advisories, 662 KB

References PDF 8. References, 464 KB

Glossary PDF 9. Glossary, 179 KB

Appendices PDF Appendices, 1.2 MB

A. ATSDR minimal risk level worksheets
B. Updated (September 2008) ATSDR Policy Guidelne for Dioxins in Residential Soil
C. User’s guide
D. Acronyms, abbreviations, and symbols
ReferenceAgency for Toxic Substances and Disease Registry (ATSDR). 1998. Toxicological profile for Chlorinated Dibenzo-p-dioxins (CDDs). Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.Disclaimer

All ATSDR toxicological profile PDF files are electronic conversions from paper copy or other electronic ASCII text files. This conversion may have resulted in character translation or format errors. Users are referred to the original paper copy of the toxicological profile for the official text, figures, and tables. Original paper copies can be obtained via the directions on the toxicological profile home page, which also contains other important information about the profiles.

Agency for Toxic Substances and Disease Registry
Division of Toxicology and Human Health Sciences
1600 Clifton Road NE, Mailstop F-57
Atlanta, GA 30333
Phone: 1-800-CDC-INFO · 888-232-6348 (TTY)
Email: Contact CDC-INFO

ATSDR can also tell you the location of occupational and environmental health clinics. These clinics specialize in recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances.



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